Methyl iodide → HCID 13138426, compound

Participants

Reaction Steps

1-[3-(1-Methyl-1,2,3,4-tetrazol-5-yl)thiopropyl]-3-methylthiourea (8 g) is dissolved in methanol (80 ml). To the mixture is added methyl iodide (5.7 g) and the mixture is refluxed for 5 hours. To the reaction mixture is further added hydrazine hydrate (2.4 g) and the mixture is refluxed for 2 hours. After the solvent is distilled off, the resulting crystalline product is recrystallized from ethanol to give 1-amino-2-methyl-3-[3-(1-methyl-1,2,3,4-tetrazol-5-yl)thiopropyl]guanidine hydroiodide (8.5 g), colorless prisms, m.p. 105°-108° C.

Provenance & Evidence