Formic Acid → HCID 53939076, compound

HRID 1758362Notes

Reaction equation

HRID 1758362 reaction equation
[C:1](OC(=O)C)(=[O:3])C.C(O)=O.[NH2:11][C:12]1[S:13][CH:14]=[C:15]([C:17](=[N:23][O:24][CH2:25][CH2:26][Br:27])[C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:16]=1>O>[CH:1]([NH:11][C:12]1[S:13][CH:14]=[C:15]([C:17](=[N:23][O:24][CH2:25][CH2:26][Br:27])[C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:16]=1)=[O:3]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 54560759HCID 54560759, compound

Product 1

HCID 53939076HCID 53939076, compoundYield 61.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of acetic anhydride (15.9 g.) and formic acid (7.15 g.) was stirred at 50° C. for an hour. After cooling, ethyl 2-(2-aminothiazol-4-yl)-2-(2-bromoethoxyimino)acetate (syn isomer, 25 g.) was added to the solution and stirred at room temperature for an hour. The resultant solution was poured into water and extracted with ethyl acetate twice. The extracts were washed with a saturated aqueous solution of sodium chloride, a saturated aqueous solution of sodium bicarbonate (three times) and a saturated aqueous solution of sodium chloride in turn, and dried over magnesium sulfate. After concentrating the solution in vacuo, the oily residue was triturated with a mixture of diisopropyl ether and diethyl ether. The precipitates were collected by filtration to give ethyl 2-(2-formamidothiazol-4-yl)-2-(2-bromoethoxyimino)acetate (syn isomer, 16.75 g.), mp. 95° to 98° C.

Workup

  1. temperatureAfter cooling
  2. stirringstirred at room temperature for an hour
  3. extractionextracted with ethyl acetate twice
  4. washThe extracts were washed with a saturated aqueous solution of sodium chloride
  5. dry with materiala saturated aqueous solution of sodium bicarbonate (three times) and a saturated aqueous solution of sodium chloride in turn, and dried over magnesium sulfate
  6. concentrationAfter concentrating the solution in vacuo
  7. customthe oily residue was triturated with a mixture of diisopropyl ether and diethyl ether
  8. filtrationThe precipitates were collected by filtration

Sources & evidence

ORD record
ord-f54183e4201b4a6f9ea3368e8311b526
Source dataset
uspto-grants-1983_02
Patent number
US04372952

Reaction notes

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