Dicyclohexylcarbodiimide → HCID 15587193, compound

HRID 1758453Notes

Reaction equation

HRID 1758453 reaction equation
[C:1]([CH2:4][S:5][CH:6]([C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[CH2:12][CH2:11][N:10]=1)[C:7]#[N:8])(O)=[O:2].C1(N=C=NC2CCCCC2)CCCCC1>N1C=CC=CC=1>[C:7]([C:6]1[S:5][CH2:4][C:1](=[O:2])[N:10]2[CH2:11][CH2:12][C:13]3[C:18](=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=3)[C:9]=12)#[N:8]

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 15587171HCID 15587171, compound

Product 1

HCID 15587193HCID 15587193, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a pyridine solution of 3.2 g. of α-(carboxymethyl-mercapto)-6,7-dimethoxy-3,4-dihydro-1-isoquinolyl-acetonitrile 2.1 g. of dicyclohexyl-carbodiimide are added. The reaction mixture is allowed to stand at room temperature for two days. The solvent is evaporated in vacuo and the residue is recrystallized from butanol. 1.9 g. of 1-cyano-9,10-dimethoxy-3,4,6,7-tetrahydro-1,4-thiazino[3,4-a]isoquinoline-4-one are obtained, melting at 186° to 187° C. after recrystallization from butanol.

Workup

  1. customThe solvent is evaporated in vacuo
  2. customthe residue is recrystallized from butanol

Sources & evidence

ORD record
ord-ad19b464ffff4c80a6639289201c0678
Source dataset
uspto-grants-1983_02
Patent number
US04373104

Reaction notes

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