HCID 57158608, compound → N-Acetylglycyl-L-phenylalanine

HRID 1758463Notes

Reaction equation

HRID 1758463 reaction equation
[C:1]([NH:4][CH2:5][C:6]([NH:8][C:9]([C:17]([OH:19])=[O:18])=[CH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])(=[O:3])[CH3:2]>C(O)C>[C:1]([NH:4][CH2:5][C:6]([NH:8][C@H:9]([C:17]([OH:19])=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 57158608HCID 57158608, compound

Product 1

HCID 12831083N-Acetylglycyl-L-phenylalanine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In each case 4.0 grams of degassed N-acetyl-glycyl-dehydrophenylalanine were suspended in 75 ml ethanol and treated with 5.0 ml of an ethanolic solution which contained per ml 4 mg of catalyst. The hydrogenation was undertaken at 25° C. After the end of the reaction time in each case the reaction vessel was ventilated and the solvent removed under reduce pressure. In all cases there remained in the form of a white crystal mass in practically quantitative yield crude N-acetyl-glycyl-phenylalanine. The reaction conditions and results are collected in Table II

Workup

  1. customwas undertaken at 25° C
  2. customthe solvent removed

Sources & evidence

ORD record
ord-92ab0f352c60460eb88e72498e10aaca
Source dataset
uspto-grants-1983_02
Patent number
US04374062

Reaction notes

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