HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cornforth reagent → tert-Butyl 6-oxohexylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cornforth reagent | HCID 2724130 | — |
| Reactant | tert-Butyl N-(6-hydroxyhexyl)carbamate | HCID 4146612 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Diethylether pentane | HCID 21877078 | — |
| Product | tert-Butyl 6-oxohexylcarbamate | HCID 10536636 | 80% |
Reaction Steps
Pyridinium dichromate (13.5 g, 0.036 mol) is added to a solution of t-butyl-(6-hydroxyhexyl)carbamate (5.88 g, 24 mmol) in dichloromethane (40 ml). After stirring for 24 hours, the reaction mixture is diluted with diethylether/pentane (1:1), filtered through Florisil and concentrated to yield t-butyl-(5-formylpentyl)carbamate (4.13 g, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04374128 |
| Source dataset | uspto-grants-1983_02 |
| ORD ID | ord-4aa93656811145dfa786947a2e676a31 |
| Source note | uspto-grants-1983_02 |