HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isocyanate → 6-[[(Ethylamino)carbonyl]amino]-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acid | HCID 13106330 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-[[(Ethylamino)carbonyl]amino]-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid | HCID 20509394 | 93% |
Reaction Steps
A mixture of 4.08 g (20 mmol) of 6-amino-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid, 2.37 ml (30 mmol) of ethyl isocyanate, 2.8 ml (20 mmol) of triethylamine and 50 ml of dimethylformamide is stirred with ice bath cooling for 4.5 hrs. The reaction solution is evaporated to dryness and is treated with 1 N hydrochloric acid and ethanol to yield 5.12 g of 6-[[(ethylamino)carbonyl]amino]-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04374138 |
| Source dataset | uspto-grants-1983_02 |
| ORD ID | ord-ba06a6fcf0a248d09451586b186ec9ee |
| Source note | uspto-grants-1983_02 |