反应详情

To a stirred solution of spiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (5.0 g) in dry benzene (18 ml) is added methylisothiocyanate (3.1 g) in dry benzene (10 ml). After one hour, the product begins to separate. The mixture is stirred overnight and diluted with hexane (18 ml). The product is filtered, washed with hexane and dried to yield a solid. The solid is twice recrystallized from benzene to yield (3.0 g, 46%) as a solid, mp 165°.166°.

1. customto separate
2. additiondiluted with hexane (18 ml)
3. filtrationThe product is filtered
4. washwashed with hexane
5. customdried
6. customto yield a solid
7. customThe solid is twice recrystallized from benzene
8. customto yield (3.0 g, 46%) as a solid, mp 165°
9. custom166°