HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Carbamoyl-4,5-difluorobenzoic acid → 5,6-Difluoroisoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Carbamoyl-4,5-difluorobenzoic acid | HCID 14774002 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5,6-Difluoroisoindoline-1,3-dione | HCID 14818212 | — |
Reaction Steps
One part of the 4,5-difluorophthalamic acid was heated to 170° C. for a period of 30 minutes, then cooled, dissolved in toluene and crystallized therefrom. The crystalline product was separated by filtration to yield 0.56 parts of 4,5-difluorophthalimide, having a melting range of 154°-156° C. The structure was confirmed by C13 nuclear magnetic resonance analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04374266 |
| Source dataset | uspto-grants-1983_02 |
| ORD ID | ord-4b5b4bda37f64769bbe84c5238daece4 |
| Source note | uspto-grants-1983_02 |