Sodium Hydroxide → 4-[2-[[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]methylsulfanyl]ethylamino]-1,1-dioxo-1,2,5-thiadiazol-3-one

HRID 1758636Notes

Reaction equation

[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]2[C:19]([O:20]C)=[N:18][S:17](=[O:23])(=[O:22])[N:16]=2)[N:9]=1)[CH3:3].[OH-].[Na+]>>[CH3:3][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]2[C:19]([OH:20])=[N:18][S:17](=[O:22])(=[O:23])[N:16]=2)[N:9]=1)[CH3:1]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 178494331HCID 178494331, compound

Product 1

HCID 1784833164-[2-[[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]methylsulfanyl]ethylamino]-1,1-dioxo-1,2,5-thiadiazol-3-one

Procedure

When a solution of 3-{2-[(2-dimethylaminomethyl-4-thiazolyl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide [prepared according to the procedure described in Example 33, Step F] is reacted with sodium hydroxide according to the procedure described in Example 17, Step B, the title compound is produced.

Sources & evidence

ORD record: ord-487eccf20ae3489c90c13a428ca785a7
Source dataset: uspto-grants-1983_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04374248

Reaction notes

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