Formaldehyde → HCID 12797625, compound

HRID 1758762Notes

Reaction equation

HRID 1758762 reaction equation
[CH2:1]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:2][CH:3]([CH3:5])[CH3:4].[CH2:19]=O>C(O)=O>[CH2:1]([N:6]([CH3:19])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:2][CH:3]([CH3:4])[CH3:5]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 12797624HCID 12797624, compound

Product 1

HCID 12797625HCID 12797625, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

To 30 g of N-isoamyldodecanamine in 100 ml of formic acid was added 30 ml of formalin (40% formaldehyde) and the reaction mixture was refluxed for 8 hours. Most of the solvent was removed under vacuum and the remaining material was made alkaline with 3 N sodium hydroxide solution and the amine extracted into hexane. The hexane phase was washed with water, and then dried over sodium hydroxide pellets. Removal of the hexane under vacuum gave 28 g of N-isoamyl-N-methyldodecanamine, ND20 1.4507.

Workup

  1. temperaturethe reaction mixture was refluxed for 8 hours
  2. customMost of the solvent was removed under vacuum
  3. extractionthe amine extracted into hexane
  4. washThe hexane phase was washed with water
  5. dry with materialdried over sodium hydroxide pellets
  6. customRemoval of the hexane under vacuum

Sources & evidence

ORD record
ord-6246374e8a334943859c5405adaa6d03
Source dataset
uspto-grants-1983_02
Patent number
US04374850

Reaction notes

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