Chloroacetyl chloride → HCID 13068336, compound

HRID 1758764Notes

Reaction equation

HRID 1758764 reaction equation
[O:1]=[C:2]1[CH2:8][O:7][CH:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([F:18])([F:17])[F:16])[C:5]2[CH:19]=[CH:20][CH:21]=[CH:22][C:4]=2[NH:3]1.[Cl:23]CC(Cl)=O>C1C=CC=CC=1>[Cl:23][CH2:8][C:2]([NH:3][C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[C:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]([F:18])([F:17])[F:16])=[O:7])=[O:1]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 13068341HCID 13068341, compound

Product 1

HCID 13068336HCID 13068336, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 2-amino-2'-trifluoromethyl-benzophenone 1 [L. H. Sternbach et al. Helv. Chim. Acta., 45, 2226 (1962)](8 g) in benzene (80 ml) is added chloroacetyl chloride (29 ml), and the mixture is refluxed under heating for 30 minutes. Benzene is evaporated under reduced pressure, and the residue is washed with n-hexane to give crystalline 2-(2-chloroacetyl)amino-2'-trifluoromethylbenzophenone (10.05 g), which is recrystallized from benzene-n-hexane to give the pure crystals, mp. 79°-81° C.

Workup

  1. temperaturethe mixture is refluxed
  2. temperatureunder heating for 30 minutes
  3. customBenzene is evaporated under reduced pressure
  4. washthe residue is washed with n-hexane

Sources & evidence

ORD record
ord-a024e1ce53fd4610b9d861a32da091f9
Source dataset
uspto-grants-1983_02
Patent number
US04374842

Reaction notes

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