Sodium Methoxide → HCID 13105786, compound

HRID 1758767Notes

Reaction equation

HRID 1758767 reaction equation
CS[C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[CH:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3Cl)[O:11][CH2:12][C:6]2=[N:5][N:4]=1.[CH3:25][O-:26].[Na+]>CO>[O:26]1[CH2:12][CH2:6][N:7]([C:3]2[N:7]3[C:8]4[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=4[CH:10]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[O:11][CH2:12][C:6]3=[N:5][N:4]=2)[CH2:3][CH2:25]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 13068329HCID 13068329, compound

Product 1

HCID 13105786HCID 13105786, compoundYield 130%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of Compound 15 (0.76 g) prepared in Example 8-(1) in methanol (20 ml) is added sodium methoxide (0.119 g), and the mixture is stirred for 4 hours, allowed to stand overnight, and concentrated. The residue is extracted with chloroform and the extract is washed with water, dried, and concentrated. The residue is washed with ethyl acetate to give Compound 19 (0.5 g) in 66.5% yield.

Workup

  1. waitto stand overnight
  2. concentrationconcentrated
  3. extractionThe residue is extracted with chloroform
  4. washthe extract is washed with water
  5. customdried
  6. concentrationconcentrated
  7. washThe residue is washed with ethyl acetate

Sources & evidence

ORD record
ord-9b2d61b32d914f129f71d291efed825a
Source dataset
uspto-grants-1983_02
Patent number
US04374842

Reaction notes

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