Sodium Hydroxide → HCID 20508547, compound

Participants

Reaction Steps

22.6 g (64.5 mmol) of 6-(o-fluorophenyl)-4,4-dimethyl-8-nitro-4H-s-triazolo[4,3-a][1,4]benzodiazepine, dissolved in 200 ml of concentrated hydrochloric acid, are treated portionwise with a total of 43.66 g (0.19 mol) of tin chloride in such a manner that the temperature does not exceed 85° C. The mixture is stirred at room temperature for a further 1 hour, cautiously neutralised with 10 N sodium hydroxide while cooling with ice and extracted with chloroform/ethanol (9:1) in a perforator. After removing the solvent, the residue is suspended in hot ethyl acetate and filtered off, there being obtained 8-amino-6-(o-fluorophenyl)-4,4-dimethyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine of melting point 288° C.

Provenance & Evidence