3-Carboxy-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid → Zomepirac

Participants

Reaction Steps

Two hundred and thirty-five milligrams of 5-(p-chlorobenzoyl)-1,4-dimethyl-3-hydroxycarbonyl-pyrrole-2-acetic acid is dissolved in 5 ml of trifluoroacetic acid and the resulting solution is heated to reflux for 1.5 hours. After most of the solvent is removed in vacuo, the residue is treated with 10 ml of water. The resulting residue is filtered and dried in vacuo to give 5-(p-chlorobenzoyl)-1,4-dimethyl-pyrrole-2-acetic acid (Zomepirac) in 91% yield, m.p. 184°-185° C.

Provenance & Evidence