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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1758847Generated: October 31, 2026

2-Oxo-4-phenylbutyric acid → N-(1-carboxy-3-phenylpropyl)-L-phenylalanyl-L-proline

https://huagongshe.com/reaction/1758847

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Oxo-4-phenylbutyric acidHCID 69732—
ReactantSodium cyanoborohydrideHCID 5003444—
ReactantPhe-ProHCID 7020642—
ProductN-(1-carboxy-3-phenylpropyl)-L-phenylalanyl-L-prolineHCID 54222365—

Reaction Steps

In the manner described in example 24, 2-oxo-4-phenylbutyric acid and L-phenylalanyl-L-proline are condensed in the presence of sodium cyanoborohydride to yield N-(1-carboxy-3-phenylpropyl)-L-phenylalanyl-L-proline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04374829
Source datasetuspto-grants-1983_02
ORD IDord-6ef106b8cc884b4bb170c390be2c31c9
Source noteuspto-grants-1983_02