L-Alanyl-L-proline → HCID 6321214, compound

Participants

Reaction Steps

A mixture of 0.814 g of L-alanyl-L-proline, 0.206 g of ethyl 2-oxo-4-phenylbutyrate, and 1.6 g of molecular sieves in 10 ml ethanol is hydrogenated at room temperature under 40 pounds pressure with 0.1 g of 10% Pd on carbon as catalyst. After uptake of hydrogen ceases the crude product obtained by filtration and concentration is absorbed on ion exchange resin, (Dowex 50, H+) and eluted with 2% pyridine in water to yield 0.224 g of N-(1-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline. HPLC indicates a 55:45 isomer ratio.

Provenance & Evidence