Benzoyl chloride → HCID 54521070, compound

HRID 1758867Notes

Reaction equation

[NH2:1][CH:2]([CH2:22][CH:23]([CH3:25])[CH3:24])[CH:3]([NH:9][CH:10]([C:12]([N:14]1[CH2:21][CH2:20][CH2:19][C@H:15]1[C:16]([OH:18])=[O:17])=[O:13])[CH3:11])[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:26](Cl)(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[C:26]([NH:1][CH:2]([CH2:22][CH:23]([CH3:24])[CH3:25])[CH:3]([NH:9][CH:10]([C:12]([N:14]1[CH2:21][CH2:20][CH2:19][C@H:15]1[C:16]([OH:18])=[O:17])=[O:13])[CH3:11])[C:4]([O:6][CH2:7][CH3:8])=[O:5])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 54071207HCID 54071207, compound

Product 1

HCID 54521070HCID 54521070, compound

Procedure

By treating a solution of N-(2-amino-1-ethoxycarbonyl-4-methylpentyl)-D,L-alanyl-L-proline (prepared as described in Example 79) in organic solvent with benzoyl chloride, one can obtain N-(2-benzamido-1-ethoxycarbonyl-4-methylpentyl)-D,L-alanyl-L-proline.

Sources & evidence

ORD record: ord-62afb3f5d2c440ce85b3c77e3cafbc12
Source dataset: uspto-grants-1983_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04374829

Reaction notes

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