Sulfuric Acid → HCID 12918689, compound

Participants

Reaction Steps

A 1-liter 1-neck R.B. flask was charged with 156.61 g (0.50 Mol) of ethyl-5-(2',4'-dichlorophenyl)-5-cyano-4-ketopentanoate, 153 ml of concentrated sulfuric acid, 153 ml of water, and 440 ml of glacial acetic acid. The reaction mixture was stirred and refluxed for 24 hours. The reaction mixture was cooled to room temperature and 300 ml of water added followed by 200 ml of isopropyl ether. The mixture was refluxed for 1/2 hour, cooled in an ice bath, and filtered. The desired acid (104.13 g, 80% yield) was obtained as a viscous dark-colored oil.

Provenance & Evidence