O-Toluidine → HCID 13057309, compound

Participants

Reaction Steps

To a 25 ml of dry chloroform, 5.4 g (0.03 m) methyl hydrogen phthalate and 3.9 g (0.033 m) thionyl chloride is added. Stir and reflux for 3 hours and cool to room temperature. To this solution 2.3 g (0.03 m) ammonium thiocyanate is added and the mixture is stirred for 3 hours at room temperature until it changed to bellow. Finally, 3.2 g (0.03 m) 2-methylaniline is added and stirred at room temperature overnight. The mixture is added to water and then some hexane is added to give fine precipitates. Filter, wash with water, hexane and dry to give 6.1 g, desired product, m.p. 143-45, yield 62%.

Provenance & Evidence