2-Amino-5-(trifluoromethyl)pyridine → 1-(2,6-Difluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

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Reaction Steps

An 0.7 g. portion of 5-trifluoromethyl-2-aminopyridine was dissolved in 20 ml. of acetonitrile, and to the solution was added 0.85 g. of 2,6-difluorobenzoyl isocyanate under a nitrogen blanket at ambient temperature. A precipitate formed immediately. The mixture was stirred for 3 hours, and was then filtered and the solids were washed with acetonitrile. The solids were dried under vacuum to obtain 1.0 g. of the product named above, m.p. 215°-220° C. Elemental analysis gave the following results:

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