2-Amino-5-bromopyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

HRID 1758924Notes

Reaction equation

HRID 1758924 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[Cl:9][C:10]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:11]=1[C:12]([N:14]=[C:15]=[O:16])=[O:13]>C(#N)C>[Cl:9][C:10]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:11]=1[C:12]([NH:14][C:15]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1)=[O:16])=[O:13]

Participants

4

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 130517312-Chloro-6-fluorobenzoyl isocyanate

Product 1

HCID 130230741-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

An 0.4 g. portion of 5-bromo-2-aminopyridine was dissolved in 20 ml. of acetonitrile, and was reacted with 0.5 g. of 2-chloro-6-fluorobenzoyl isocyanate as described in Example 1. The yield was 0.5 g. of the desired product, m.p. 207°-213° C. Elemental analysis gave the following results:

Sources & evidence

ORD record
ord-cfd4b7bf557d43e89185540fe0bc15d4
Source dataset
uspto-grants-1982_07
Patent number
US04338321

Reaction notes

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