2-Amino-5-bromopyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

HRID 1758930Notes

Reaction equation

HRID 1758930 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[C:3]=1[C:4]([NH:6][C:7](Cl)=[O:8])=[O:5].[Br:15][C:16]1[CH:17]=[CH:18][C:19]([NH2:22])=[N:20][CH:21]=1>>[Cl:1][C:2]1[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[C:3]=1[C:4]([NH:6][C:7]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([Br:15])=[CH:21][N:20]=1)=[O:8])=[O:5]

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 537976672-Chloro-6-fluorobenzamidocarboxylic acid chloride

Product 1

HCID 130230741-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

Procedure

To a portion of 2-chloro-6-fluorobenzamidocarboxylic acid chloride dissolved in an organic solvent, a hydrogen halide acceptor is added, and a portion of 5-bromo-2-aminopyridine is added. After a period of stirring, the reaction mixture is washed with water and neutralized, and the product named in the heading is isolated as described in Example 12. The product is identical to that of Example 2 above.

Workup

  1. washthe reaction mixture is washed with water
  2. customis isolated

Sources & evidence

ORD record
ord-20526ed36177422b8c3201ae0a36901e
Source dataset
uspto-grants-1982_07
Patent number
US04338321

Reaction notes

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