反应详情

温度

80 °C

A mixture of 13 parts of powdered potassium hydroxide (85% purity), 15 parts of 1H-1,2,4-triazole and 165 parts of dimethylsulfoxide is heated at 80° C. for 1 hour. 58 Parts of 2-(2,4-dichlorophenyl)-2-(bromomethyl)-4-(methoxymethyl)-1,3-dioxolane are added and the whole is heated at 150° C. for 12 hours. The reaction mixture is poured onto 1000 parts of water. The product is extracted with 1,1'-oxybisethane. The extract is dried, filtered and evaporated. The residue is distilled under high vacuum yielding pure 1-[2-(2,4-dichlorophenyl)-4-(methoxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole; bp. 161°-168° C. at 0.01 mm. pressure. The product crystallizes on standing, yielding a solid having a melting point of 64°-74° C.

1. temperaturethe whole is heated at 150° C. for 12 hours
2. extractionThe product is extracted with 1,1'-oxybisethane
3. customThe extract is dried
4. filtrationfiltered
5. customevaporated
6. distillationThe residue is distilled under high vacuum