HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol → N-[2-(4-(1-Carboethoxy)ethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl) ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol | HCID 12944834 | — |
| Reactant | 1-(4-(1-Carboethoxy)ethoxyphenyl) propan-2-one | HCID 54473590 | — |
| Product | N-[2-(4-(1-Carboethoxy)ethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl) ethanamine | HCID 54155548 | — |
Reaction Steps
The compound was prepared as in Example 1 from 1-(4-(1-carboethoxy)ethoxyphenyl) propan-2-one (1.22 g) and 2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl) ethanamine (0.95 g), and crystallised from benzene m.p. 53°-55° as a 53:47 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04338333 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-5d39b5b69003408ab00c151fe486721e |
| Source note | uspto-grants-1982_07 |