4-(2-Amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol → HCID 53825218, compound

HRID 1758977Notes

Reaction equation

HRID 1758977 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14](=O)[CH3:15])[CH:10]=[CH:11][CH:12]=1)([O:3][CH3:4])=[O:2].[OH:17][CH:18]([C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([CH2:28][OH:29])[CH:22]=1)[CH2:19][NH2:20]>>[C:1]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH2:13][CH:14]([NH:20][CH2:19][CH:18]([OH:17])[C:21]2[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([CH2:28][OH:29])[CH:22]=2)[CH3:15])[CH:10]=[CH:11][CH:12]=1)([O:3][CH3:4])=[O:2]

Participants

3

Reactant 2

HCID 129448344-(2-Amino-1-hydroxyethyl)-2-(hydroxymethyl)phenolHCID 20533273Methyl [3-(2-oxopropyl)phenoxy]acetate

Product 1

HCID 53825218HCID 53825218, compound

Procedure

The compound was prepared as in Example 1 from 1-(3-carbomethoxymethoxyphenyl) propan-2-one (1.82 g) and 2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl) ethanamine (1.5 g) and crystallised from benzene m.p. 60°-64° as a 42:58 mixture of diastereoisomers.

Workup

  1. customcrystallised from benzene m.p. 60°-64° as a 42:58 mixture of diastereoisomers

Sources & evidence

ORD record
ord-5fca427d3d024d5684e79b661c0e9ec3
Source dataset
uspto-grants-1982_07
Patent number
US04338333

Reaction notes

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