HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol → N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-trifluoromethylphenyl) ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol | HCID 30514 | — |
| Reactant | Methyl 2-(4-(2-oxopropyl)phenoxy)acetate | HCID 13851156 | — |
| Product | N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-trifluoromethylphenyl) ethanamine | HCID 19874581 | — |
Reaction Steps
The compound was prepared as in Example 5 from 1-(4-carbomethoxymethoxyphenyl)propan-2-one (2.22 g) and 2-hydroxy-2-(3-trifluoromethylphenyl) ethanamine (2.05 g). The compound crystallised from hexane m.p. 70°-85° as a 1:1 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04338333 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-e5afe5420cdd4f5da5e6df6b5c83eb53 |
| Source note | uspto-grants-1982_07 |