Ammonia → HCID 20533261, compound

HRID 1758983Notes

Reaction equation

HRID 1758983 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:16][CH2:17][CH:18]([OH:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH3:15])=[CH:9][CH:8]=1)(OC)=[O:2].[NH3:26]>CO>[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:16][CH2:17][CH:18]([OH:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH3:15])=[CH:9][CH:8]=1)(=[O:2])[NH2:26]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20533256HCID 20533256, compound

Product 1

HCID 20533261HCID 20533261, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-phenylethanamine (0.5 g) in methanol (10 ml) was treated with a solution of 0.880 ammonia (40 ml), the resulting mixture boiled for 11/2 hours then stirred at ambient temperature for 18 hours. The resulting white precipitate was filtered off to yield the title compound (0.17 g) m.p. 158°-162°, as an 82:18 mixture of diastereoisomers.

Workup

  1. custom2 hours
  2. filtrationThe resulting white precipitate was filtered off

Sources & evidence

ORD record
ord-b553ff3f1bf2437590c6a1bc7b9bda69
Source dataset
uspto-grants-1982_07
Patent number
US04338333

Reaction notes

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