HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-(4-(2-oxopropyl)phenoxy)acetate → N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-fluorophenyl) ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-(4-(2-oxopropyl)phenoxy)acetate | HCID 13851156 | — |
| Reactant | 2-Amino-1-(2-fluorophenyl)ethan-1-ol | HCID 15067176 | — |
| Product | N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-fluorophenyl) ethanamine | HCID 54369821 | — |
Reaction Steps
The compound was prepared as in Example 5 from 1-(4-carbomethoxymethoxyphenyl) propan-2-one (2.22 g) and 2-hydroxy-2-(2-fluorophenyl) ethanamine (1.55 g), and crystallised from hexane m.p. 60°-80° as a 55:45 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04338333 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-e79f7922604f465eb86363231a5c5c3a |
| Source note | uspto-grants-1982_07 |