Propanal → HCID 178438255, compound

HRID 1759007Notes

Reaction equation

HRID 1759007 reaction equation
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[CH:7](=O)[CH2:8][CH3:9].N1C=CC=CC=1.[C:17](Cl)(=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19]>C1(C)C=CC=CC=1>[CH2:8]([CH:9]1[S:6][C:3]([NH:2][CH3:1])=[N:4][N:5]1[C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])[CH3:7]

Participants

6

Reactant 4

HCID 527PropanalHCID 1049PyridineHCID 62493Pivaloyl chlorideHCID 2723853N-Methylhydrazinecarbothioamide

Product 1

HCID 178438255HCID 178438255, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 10.5 g. portion of 4-methylthiosemicarbazide was reacted with 5.8 g. of propionaldehyde in the presence of 7.9 g. of pyridine and 200 ml. of toluene, and 12.1 g. of pivaloyl chloride was added to produce 13.8 g. of the desired product, m.p. 78.5°-80°.

Workup

  1. customto produce 13.8 g

Sources & evidence

ORD record
ord-c65f72e50f2f4b63946ce9c0ba228e62
Source dataset
uspto-grants-1982_07
Patent number
US04338449

Reaction notes

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