Dichloromethane → tert-Butyl 1-(1-(3,5-difluorobenzyl)-5-bromo-1H-imidazol-2-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethylcarbamate
Reaction equation
[Br:43][N:44]1[C:45](=[O:46])[CH2:47][CH2:48][C:49]1=[O:50].[CH2:51]([Cl:52])[Cl:53].[F:1][c:2]1[cH:3][c:4]([CH2:5][n:6]2[c:7]([CH:11]([CH2:12][c:13]3[cH:14][c:15]4[cH:16][n:17]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:28])([CH3:29])[CH3:30])[n:18][c:19]4[c:20]([CH3:22])[cH:21]3)[NH:31][C:32]([O:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[n:8][cH:9][cH:10]2)[cH:39][c:40]([F:42])[cH:41]1>>[F:1][c:2]1[cH:3][c:4]([CH2:5][n:6]2[c:7]([CH:11]([CH2:12][c:13]3[cH:14][c:15]4[cH:16][n:17]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:28])([CH3:29])[CH3:30])[n:18][c:19]4[c:20]([CH3:22])[cH:21]3)[NH:31][C:32]([O:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[n:8][cH:9][c:10]2[Br:43])[cH:39][c:40]([F:42])[cH:41]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-d3846befe088456c893a058c2cad4bab
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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