M-Cresol → HCID 53754896, compound

HRID 1759145Notes

Reaction equation

HRID 1759145 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:8].[Cl:9][C:10]1[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[C:14]([Cl:21])=[CH:13][C:11]=1[NH2:12].[OH-].[Na+]>O>[CH3:8][C:2]1[CH:1]=[C:6]([O:7][S:17]([C:15]2[CH:16]=[C:10]([Cl:9])[C:11]([NH2:12])=[CH:13][C:14]=2[Cl:21])(=[O:19])=[O:18])[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 342M-CresolHCID 14798Sodium HydroxideHCID 27564014-Amino-2,5-dichlorobenzenesulfonyl chloride

Product 1

HCID 53754896HCID 53754896, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

110 g of m-cresol are dissolved in 1.5 liters of water at 60° C. and pH 10.5. 497 g of a 52.4% strength moist paste of 2,5-dichloro-aniline-4-sulphonic acid chloride are added in portions, over the course of 45 minutes, to this solution at 60° C. At the same time, the pH value is kept constant at between 10.0 and 10.5 by simultaneous dropwise addition of a total of 100 ml of a 45% strength sodium hydroxide solution. The mixture is then stirred for a further 30 minutes, after which the precipitate obtained is filtered off, washed until neutral and dried at 60° C. in a vacuum drying cabinet. 275 g of 4-amino-2,5-dichlorobenzenesulphonic acid 3-methyl-phenyl ester are obtained. ##STR7##

Workup

  1. customafter which the precipitate obtained
  2. filtrationis filtered off
  3. washwashed until neutral and
  4. customdried at 60° C. in a vacuum
  5. customdrying cabinet

Sources & evidence

ORD record
ord-1a34b1ce17d34c40b67286638076c96c
Source dataset
uspto-grants-1982_07
Patent number
US04339380

Reaction notes

Loading…