Hydroxyamine hydrochloride → N-{[5-(3,4-Dimethoxyphenyl)furan-2-yl]methylidene}hydroxylamine

Participants

Reaction Steps

5-(3,4-Dimethoxyphenyl)furaldehyde (100 g, 0.43 mole), hydroxylamine hydrochloride (59.9 g, 0.86 mole) and anhydrous sodium acetate (70.69 g) was treated with solution of water (150 ml) in SDA #32 (2200 ml). The reaction mixture was heated at reflux for 6 hours. The mixture was filtered hot and the filtrate chilled. The intermediate was collected and used without further purification in Part B; 38 g (36%), m.p. 148°.

Provenance & Evidence