1-Butanol → HCID 13067038, compound

Participants

Reaction Steps

To a well-stirred slurry of 2,4-dichloropyrimidine (27.0 g, 0.18 m) and n-butanol (150 ml) is added 150 ml of water followed immediately by n-dodecylamine (67.2 g, 0.36 m). The clear solution obtained after a short time gradually clouds as the product precipitates. After allowing to stir about 40 hours, the mixture is filtered, the semi-dry cake is flushed several times with small portions of water, washed twice with water and finally sucked dry to yield 29.2 g (64%) of 2-chloro-4-(n-dodecylamino)pyrimidine, m.p. 80°-82° C.

Provenance & Evidence