Pyrimidine → HCID 13067041, compound

Participants

Reaction Steps

A mixture of 2-chloro-4-(3-hydroxypropylamino)pyrimidine (37 g, 0.2 m), n-dodecylamine (81.5 g, 0.44 m), ethanol (2.5 l) and water (250 ml) is heated under reflux until thin layer chromatography (silica gel; 7.5 parts by volume chloroform, 0.5 parts by volume concentrated ammonium hydroxide, and 2.0 parts by volume methanol) indicates absence of the pyrimidine starting material. After concentration of the mixture, the residue is taken up in methylene chloride, and filtered from some n-dodecylamine hydrochloride. The organic solution is washed with water, dried and concentrated, and the residue is chromatographed on silica gel using a chloroform-ethanol eluant system (0-10% by volume of ethanol) to yield 56 g of 2-n-dodecylamino-4-(3-hydroxypropylamino)pyrimidine, m.p. 58°-59° C.

Provenance & Evidence