HCID 70505323, compound → HCID 13022552, compound

HRID 1759240Notes

Reaction equation

HRID 1759240 reaction equation
[CH3:1][C:2]1([CH3:30])[NH:6][CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4](=[O:13])[N:3]1[C@@H:14]1[C:28](=[O:29])[N:16]2[C:17]([C:22]([O:24]COC)=[O:23])=[C:18]([Cl:21])[CH2:19][S:20][C@H:15]12>CO>[CH3:1][C:2]1([CH3:30])[NH:6][CH:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:4](=[O:13])[N:3]1[C@@H:14]1[C:28](=[O:29])[N:16]2[C:17]([C:22]([OH:24])=[O:23])=[C:18]([Cl:21])[CH2:19][S:20][C@H:15]12

Participants

3

Reactant 1

HCID 70505323HCID 70505323, compound

Product 1

HCID 13022552HCID 13022552, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.5 g of methoxymethyl 7β-(2,2-dimethyl-5-oxo-4-phenylimidazolidin-1-yl)-3-chloro-3-cephem-4-carboxylate in 10 ml of methanol is refluxed for 1 hour, and the reaction mixture is concentrated to a third volume and stirred for 30 minutes under ice-cooling. The resulting precipitate is collected by filtration and dried under reduced pressure to yield 0.4 g of 7β-(2,2-dimethyl-5-oxo-4-phenylimidazolidin-1-yl)-3-chloro-3-cephem-4-carboxylic acid.

Workup

  1. concentrationthe reaction mixture is concentrated to a third volume
  2. temperaturecooling
  3. filtrationThe resulting precipitate is collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-9a77471c5060465894174d0b5a91c432
Source dataset
uspto-grants-1982_07
Patent number
US04339575

Reaction notes

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