Chloroform → HCID 13034463, compound

Participants

Reaction Steps

Compound I (15.1 g.) was suspended in ether and LiAlH4 (1.5 g.; 0.75 equiv.) was added portionwise at room temperature. The mixture was stirred for 1 hr. at room temperature. The mixture was treated with wet THF and the mixture filtered. The filtrate was treated with CHCl3 /H2O, the CHCl3 separated, dried and the solvent removed in vacuo. Yield, 9 g. The filter-cake was stirred repeatedly with CHCl3 and an additional 4.1 g. of material was obtained. The 13.1 g. was chromatographed on a silica gel column. Compound II was eluted with CHCl3. Yield, 6.82 g. (44.9% yield).

Provenance & Evidence