HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → N-Methyl-1-Deoxynojirimycin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | (3R,4S,5R,6R)-6-(Hydroxymethyl)-2,3,4,5-piperidinetetrol | HCID 65242 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Methyl-1-Deoxynojirimycin | HCID 92381 | 81% |
Reaction Steps
179 mg of nojirimycin is dissolved in 20 ml of a 50% water-containing ethanol, followed by adding 1 ml of formalin, adding 100 mg of palladium on carbon catalyst and carrying out a catalytic reduction at ordinary temperature and under atmospheric pressure. The subsequent treatments are carried out in the same manner as in Example 2 to obtain 144 mg (81%) of N-methyl moranoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04339585 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-e6756b2e29234c909cd9d3ae9183869f |
| Source note | uspto-grants-1982_07 |