Sulfuric Acid → HCID 13035411, compound

HRID 1759260Notes

Reaction equation

HRID 1759260 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:9][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:7]C1=O.S(=O)(=O)(O)O>O.[OH-].[K+]>[NH2:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:9][NH:5][CH2:4][CH2:3][O:2][CH3:1]

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 128034231-(2-Methoxyethyl)-4-phenylimidazolidin-2-one

Product 1

HCID 13035411HCID 13035411, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14797Potassium HydroxideSolvent

Procedure

The racemic 1-(2-methoxyethyl)-4-phenyl-2-imidazolidone (2.2 g) obtained is heated at 140°-150° C. for 20 hours with 60 weight percent sulfuric acid. The solution is cooed to room temperature, diluted with water and 20% potassium hydroxide to attain a pH of 10 and extracted with methylene chloride. The extracts are washed, dried and concentrated to yield racemic N-(2-amino-2-phenylethyl)-2-methoxyethylamine, [α]D20 =-0.00 (c=1, CHCl3).

Workup

  1. customis cooed to room temperature
  2. extractionextracted with methylene chloride
  3. washThe extracts are washed
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-537e0058bdcb4a4aa77d984b6860fbae
Source dataset
uspto-grants-1982_07
Patent number
US04339603

Reaction notes

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