Acetyl bromide → HCID 20531733, compound

Participants

Reaction Steps

A mixture of 1 g of 2-allyl-8-chloro-6,7-dihydroxy-4-(p-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide, 1.3 ml of acetyl bromide and 200 ml of trifluoroacetic acid is stirred at 10° for 2 hours. After evaporation to dryness, the residue is purified, if necessary, by recrystallization to give 2-allyl-8-chloro-6,7-diacetoxy-4-(p-acetoxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide. Similarly tri-isobutyryloxy, -propionyloxy, -isovaleryloxy, -n-butyryloxy and -n-heptanoyloxy ester derivatives are prepared.

Provenance & Evidence