反应详情

A mixture of 1.85 g. (0.0058 m) of N-(2-methoxybenzyl)-1-(3,4-dimethoxyphenyl)-2-aminoethanol prepared as in Example 3, 4.8 ml of 90% formic acid and 4.5 ml of 37% formaldehyde was heated in a steam bath for 18 hours. The aqueous portion was evaporated and the residue redissolved in water. After making the solution acid with concentrated hydrochloroic acid, the mixture was heated for 20 minutes, cooled, made basic and extracted with chloroform. The organic extract was washed with water, brine then dried. Evaporation gave 1.8 g (93%) of N-(2-methoxybenzyl)-1-(3,4-dimethoxyphenyl)-N-methyl-2-amino ethanol as an oil.

1. additionA mixture of 1.85 g
2. temperaturewas heated in a steam bath for 18 hours
3. customThe aqueous portion was evaporated
4. dissolutionthe residue redissolved in water
5. concentrationwith concentrated hydrochloroic acid
6. temperaturethe mixture was heated for 20 minutes
7. temperaturecooled
8. extractionextracted with chloroform
9. extractionThe organic extract
10. washwas washed with water, brine
11. customthen dried
12. customEvaporation