Acetyl bromide → HCID 20531692, compound

Participants

Reaction Steps

A mixture of 1.0 g of 8-hydroxy-1-(3,4-dihydroxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide prepared as in Example 4 above and 200 ml of trifluoroacetic acid is mixed with 1.3 ml of acetyl bromide. After heating at reflux for 2 hours, the mixture is evaporated to dryness. The residue is purified by recrystallization to give 8-acetoxy-1-(3,4-diacetoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide. Similarly isobutyryloxy, propionyloxy, isovaleryloxy, n-butylryloxy and n-heptanoyloxy derivatives are prepared.

Provenance & Evidence