Sulfuric Acid → HCID 13022625, compound

Participants

Reaction Steps

3.2 g of 1-n-butyl-4-chloro-2-phenyl-5-cyanomethylimidazole was heated in 18 ml of 60% sulfuric acid at 145° C. for 15 hours. The reaction solution, under cooling with ice, was made to pH 4 with 20% aqueous sodium hydroxide solution, and the deposited precipitate was recrystallized twice from 50 ml of 60% ethanol, thus yielding 2.4 g of 1-n-butyl-4-chloro-2-phenylimidazole-5-acetic acid as colorless needles, m.p. 189°-190° C.

Provenance & Evidence