Sodium Hydroxide → HCID 13022623, compound

HRID 1759323Notes

Reaction equation

HRID 1759323 reaction equation
[CH2:1]([N:8]1[C:12]([CH2:13][C:14]#[N:15])=[C:11]([Cl:16])[N:10]=[C:9]1[C:17]1[CH:22]=[CH:21][C:20]([N:23]([CH3:25])[CH3:24])=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:26].[Na+]>C(O)C>[CH2:1]([N:8]1[C:12]([CH2:13][C:14]([NH2:15])=[O:26])=[C:11]([Cl:16])[N:10]=[C:9]1[C:17]1[CH:22]=[CH:21][C:20]([N:23]([CH3:24])[CH3:25])=[CH:19][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13022619HCID 13022619, compound

Product 1

HCID 13022623HCID 13022623, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

In 50 ml of ethanol was dissolved 3.5 g of 1-benzyl-4-chloro-2-(4-dimethylaminophenyl)-5-cyanomethylimidazole, and 10 ml of 1 N-sodium hydroxide was added to the solution, followed by stirring at 60° C. for 2 hours. The solution was allowed to cool, and the resulted crystals were recrystallized from 70 ml of 90% ethanol, thereby yielding 2.2 g of 1-benzyl-4-chloro-2-(4-dimethylaminophenyl)imidazole-5-acetamide as colorless needles, m.p. 215°-216° C.

Workup

  1. additionwas added to the solution
  2. temperatureto cool
  3. customthe resulted crystals were recrystallized from 70 ml of 90% ethanol

Sources & evidence

ORD record
ord-7ab2c4eeb1774b37ad10445ead4d31ef
Source dataset
uspto-grants-1982_07
Patent number
US04340598

Reaction notes

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