Acetic Anhydride → HCID 20531677, compound

Participants

Reaction Conditions

Reaction Steps

In 30 ml of pyridine were dissolved 3.4 g of 1-benzyl-4-chloro-2-(4-dimethylaminophenyl)-5-formylimidazole and 1.39 g of hydroxylamine hydrochloride, and 6 ml of acetic anhydride was added dropwise to the solution. After the addition was completed, the reaction solution was stirred at 100° C. for 3 hours, and evaporated to dryness under reduced pressure. The residue was dissolved in 100 ml of chloroform, washed with two 300 ml portions of water, and evaporated to dryness under reduced pressure. The residue was recrystallized twice from 30 ml of ethanol, yielding 2.1 g of 1-benzyl-4-chloro-2-(4-dimethylaminophenyl)-5-cyanoimidazole as slightly brown needles, m.p. 125°-127° C.

Provenance & Evidence