18-Crown-6 → HCID 54220809, compound

Participants

Reaction Steps

A mixture of 15 g of II (R1 =CH3, X=Cl), 50 g of potassium acetate, a catalytic amount of 18-crown-6, and 60 ml of dimethylformamide was heated under nitrogen atmosphere at 130° C. for 5 hours. The mixture was poured into ice water and the solid precipitate was collected by filtration. The solid was recrystallized from 1-chlorobutane to give 11 g of 5-acetoxymethyl-3-(4-methylthiophenyl)-2-oxazolidinone (XV, R1 =CH3).

Provenance & Evidence