Dimethylformamide → HCID 13038091, compound

Participants

Reaction Steps

A mixture of 25 g (0.15 mole) of 4-acetamidothiophenol and 15 g (0.15 mole) of diisopropylamine in 80 of dimethylformamide was treated with 15 g (0.15 mole) of tetrafluoroethylene in a bomb. The temperature was slowly raised from -44° C. to 25° C. The reaction mixture was then poured into water and the solid product was isolated by filtration. The solid was dissolved in ethyl acetate and the resulting solution was dried over anhydrous magnesium sulfate, filtered, and concentrated. The solid residue was triturated with petroleum ether and filtered to give 35 g (87.5% yield) of p-(1,1,2,2-tetrafluoroethylthio)acetanilide (XI); m.p. 133.5°-135° C.

Provenance & Evidence