Glycol monoethyl ether → HCID 101835019, compound

Participants

Reaction Steps

To a solution of sodium 2-ethoxyethylate prepared by adding 7.3 g of sodium hydride (corresponding to 14.6 g in a form of a 50% suspension in liquid paraffin) to 300 ml of ethyl cellosolve, was added 55 g of sodium 2-chloro-5-nitrobenzenesulfonate. The resulting mixture was heated at 80° to 85° C. for 30 minutes with stirring. After the completion of the reaction, the insoluble substances were removed by filtration, and from the filtrate 150 ml of ethyl cellosolve was distilled under reduced pressure. To the condensed solution was added 300 ml of isopropyl alcohol, and the mixture was cooled with ice. The crystals thus precipitated were recovered by filtration, washed with 100 ml of isopropyl alcohol and air-dried. Yield 33 g m.p. 248°-249° C.

Provenance & Evidence