Sodium Hydroxide → HCID 15571271, compound

HRID 1759372Notes

Reaction equation

HRID 1759372 reaction equation
Br.[C:2]1([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:9]2([OH:19])[N:13]3[CH2:14][CH2:15][CH2:16][CH2:17][N:18]=[C:12]3[S:11][CH2:10]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[C:20]1([CH:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]2([OH:19])[N:13]3[CH2:14][CH2:15][CH2:16][CH2:17][N:18]=[C:12]3[S:11][CH2:10]2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15571272HCID 15571272, compound

Product 1

HCID 15571271HCID 15571271, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4.2 g. of 3-diphenylmethyl-2,3,5,-6,7,8-hexahydrothiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide in 50 ml. of 65% aqueous methanol is treated with 12 ml. of 1 N sodium hydroxide. The resulting solid is collected by filtration, washed with water and dried in vacuo at 40° C., giving the desired product, m.p. 123°-125° C.

Workup

  1. filtrationThe resulting solid is collected by filtration
  2. washwashed with water
  3. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-a1a64b1a9e1a4b56b1dbb2a3afb74707
Source dataset
uspto-grants-1982_07
Patent number
US04340734

Reaction notes

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