Isopropanol hydrochloride → HCID 22821028, compound

Participants

Reaction Steps

To a solution of 1.70 g (3.55 m-mol) of 5'-O-(N-benzyloxycarbonylvalyl)-2'-deoxy-5-fluorouridine obtained in Example 26 in 50 ml of isopropyl alcohol were added 10% palladium-carbon (750 mg) and a solution of 16.0% hydrogen chloride-isopropyl alcohol (810 mg). The mixture was stirred for 3.5 hours in a stream of hydrogen under normal pressure at ordinary temperature. The catalyst was filtered off and the solvent was distilled off under reduced pressure from the reaction mixture and the residue was dissolved in isopropyl alcohol (5 ml). A small amount of ether was added to this solution and the resultant white precipitate was collected by filtration in a stream of dry nitrogen whereby 1.14 g (yield: 84.1%) of 5'-O-(valyl)-2'-deoxy-5-fluorouridine hydrochloride was obtained.

Provenance & Evidence