Benzo(d)thiazol-2-amine → HCID 12874026, compound

HRID 1759384Notes

Reaction equation

HRID 1759384 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Br:11][CH2:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)=[O:14]>C(#N)C>[BrH:11].[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([C:13](=[O:14])[CH2:12][N:6]2[C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[S:3][C:2]2=[NH:1])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 8706Benzo(d)thiazol-2-amineHCID 68303p-Chlorophenacyl bromide

Product 1

HCID 12874026HCID 12874026, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a stirred solution of 7.5 parts of 2-aminobenzothiazole in 80 parts of acetonitrile are added 11.75 parts of 2-bromo-1-(4-chlorophenyl)ethanone and the whole is stirred for about 20 hours at room temperature. The precipitated product is filtered off, washed with acetonitrile, and dried, yielding 11.4 parts of 1-(4-chlorophenyl)-2-(2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide; mp. 261°-272° C.

Workup

  1. filtrationThe precipitated product is filtered off
  2. washwashed with acetonitrile
  3. customdried

Sources & evidence

ORD record
ord-724b442650b948c7a6cdf408dae390be
Source dataset
uspto-grants-1982_07
Patent number
US04340738

Reaction notes

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